Week 6 NFL odds include a rematch of last year’s epic AFC Divisional game between the Buffalo Bills and the Kansas City Chiefs, as well as games between the Dallas Cowboys and the Philadelphia Eagles on SNF and the Denver Broncos and the Los Angeles Chargers on MNF.

We’re right in the thick of it now. In NFL Week 6, contenders take the lead while pretenders fall back.
The NFL Week 6 odds feature a rematch of the infamous AFC Divisional Round game between the Bills and Chiefs, an NFC East rumble with the Cowboys visiting the Eagles on Sunday night and a Monday Night Football matchup between the Broncos and Chargers.
The Week 6 opening odds, line moves, and action reports are listed below.
NFL Week 6 Odds
These are the NFL odds for Week 6, which features a rematch of last year’s AFC Divisional Round between the Bills and Chiefs.
Matchup | Time | Spread | Over/Under |
---|---|---|---|
Commanders | Thurs, 8:15 p.m. ET | PK | 39.5 |
49ers | Sun, 1 p.m. ET | Falcons +6 | 42 |
Patriots | Sun, 1 p.m. ET | Browns -2.5 | 42 |
Jets | Sun, 1 p.m. ET | Packers -7.5 | 44.5 |
Jaguars | Sun, 1 p.m. ET | Colts -1.5 | 41 |
Vikings | Sun, 1 p.m. ET | OTB | OTB |
Bengals | Sun, 1 p.m. ET | OTB | OTB |
Ravens | Sun, 1 p.m. ET | OTB | OTB |
Buccaneers | Sun, 1 p.m. ET | Steelers +8 | 43.5 |
Panthers | Sun, 4:05 p.m. ET | Rams -9 | 42 |
Cardinals | Sun, 4:05 p.m. ET | Seahawks +2.5 | 50 |
Bills | Sun, 4:25 p.m. ET | Chiefs +1.5 | 54 |
Cowboys | Sun, 8:20 p.m. ET | Eagles -5.5 | 43.5 |
Broncos | Mon, 8:15 p.m. ET | Chargers -6.5 | 46.5 |
Teams on bye this week: Lions, Texans, Raiders, Titans.
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OKBET odds on Commanders
Opening Line: OKBET OKBET +1, 40 O/U
Why was the line moved?
9:30 P.M. SUNDAY, OCT. 9: The Bears opened as 1-point home favorites for Thursday Night Football, but this number has since risen to pick’em at some sportsbooks. The total opened at 40 points and dropped to 39.5 with early betting on the Under.
49ers Odds at OKBET
Opening Line: OKBET +5.5, O/U 42.5
Why was the line moved?
SUNDAY, OCT. 9: 10:00 P.M. The ATS record is 5-0. OKBET opened as low as +5.5 for this matchup with the 49ers, but early action favors San Francisco, pushing the spread to Niners -6. The total began with 42.5 points.
JETS ODDS AT OKBET
OKBET -7.5, over/under 45.
Why was the line moved?
10:00 P.M. SUNDAY, OCT. 9: Despite the OKBET’ loss to the Giants in London on Sunday, the OKBET return home as 7.5-point favorites. Early money has sided with Green Bay, pushing this spread to as high as -8 despite the Jets winning two of their last three games. The total began at 45 points and has since dropped to 44.5.

OKBET JETS odds
JETS -7.5, 45 over/under
Why was the line moved?
10:00 P.M. SUNDAY, OCT. 9: Despite the Packers’ loss to the Giants in London on Sunday, the Packers return home as 7.5-point favorites. Early money has sided with Green Bay, pushing this spread to as high as -8 despite the Jets winning two of their last three games. The total began at 45 points and has since dropped to 44.5.
OKBET Odds for the Jaguars
Opening Line: OKBET -1.5, over/under 41
Why was the line moved?
10:00 p.m. SUNDAY, OCT. 9: Indianapolis has had a mini-bye since eking out an ugly win last Thursday and opened as a 1.5-point home favorite against Jacksonville in Week 6. The Jaguars have lost two straight games and haven’t looked like the team that defeated the Colts in Week 3. As the week progresses, the status of Indianapolis running back Jonathan Taylor will impact this line.
